GLP-1s (Ozempic®, Wegovy®, Mounjaro®, Zepbound®) mimic a naturally occurring hormone glucagon-like peptide-1, which regulates blood sugar and appetite. Research indicates, when taken regularly, these medications can result in up to 20% weight loss. And the results go deeper than the pounds lost: a stronger heart, reduced risk of cancer, healthier joints, increased energy, and many more improvements across overall health. It’s no wonder they’ve become so popularly prescribed by physicians.
However, their side effects can be uncomfortable—leading some patients to halt treatment before achieving their desired results. The most common GLP-1 side effects are gastrointestinal (GI), including:
- Nausea and vomiting
- Diarrhea
- Constipation
If you or someone you know is experiencing uncomfortable GI side effects from GLP-1 use, the following ingredients could help. (Psst! They can also help anyone with any type of gut discomfort.)
Ginger root extract
Ginger root has a long history of treating nausea, vomiting, and indigestion. It works by speeding up gastric emptying and stimulating stomach contractions, making it a natural alternative to traditional prokinetic drugs (these increase gut motility, aka keep things flowing). Studies have also shown that ginger can help prevent nausea during chemotherapy and pregnancy.
Artichoke extract
Artichoke extract is an ideal natural remedy against bloating, nausea, and abdominal pain. By promoting bile flow and aiding in fat digestion, it enhances the digestive process and supports liver function.
Oregano leaf extract
Oregano oil is known for its antibacterial properties, which can help guard against conditions like small intestinal bacterial overgrowth (SIBO), a common issue for GLP-1 patients due to slowed digestion. Studies have shown that herbal therapies containing oregano oil are as effective as antibiotics in treating SIBO, providing a natural alternative for managing GI issues.
Peppermint leaf powder
Peppermint oil is effective in treating irritable bowel syndrome (IBS) symptoms such as diarrhea, bloating, and abdominal discomfort. Clinical studies demonstrate that peppermint oil can enhance gastric emptying and significantly reduce pain in patients with IBS.
DigeZyme (digestive enzymes)
Digestive enzymes play a crucial role in gut health by improving digestion, enhancing nutrient absorption, and alleviating symptoms of indigestion, such as bloating and gas. They support individuals with conditions like IBS, reduce symptoms of food intolerance, decrease inflammation, and balance gut microbiota.
Papain (papaya extract)
Papain, an enzyme found in papaya, helps break down dietary proteins—improving indigestion, bloating, and gas. A clinical trial showed that patients taking a papaya preparation had significant improvements in bloating and constipation compared to placebo.
Lactobacillus gasseri
This probiotic strain offers significant GI benefits by promoting a healthy balance of gut bacteria and improving digestive health. It’s been shown to alleviate bloating, abdominal pain, and irregular bowel movements. Lactobacillus gasseri can enhance the integrity of the gut lining, reducing inflammation and preventing conditions like leaky gut syndrome. It may also help regulate metabolism, counteracting metabolic changes due to weight loss medications.
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The good news is you can now get all the benefits of the above ingredients in one product. Each and every one of these GI-supporting ingredients is in Harmony-1, an all-natural supplement designed by doctors and specifically formulated for effective dosing and provides fast relief.
The benefits of GLP-1s are worth it. There are ways to mitigate these GI symptoms and reach weight-loss goals more quickly and comfortably.