Clinical Evidence

  • Ginger Root Extract 4:1 500mg

    • Ginger has long been used to treat nausea, vomiting, and indigestion by antagonizing the 5-HT3 receptor and accelerating gastric emptying and stimulating antral contractions. It may be used as a natural alternative to traditional prokinetic drugs such as metoclopramide or domperidone in a variety of clinical settings 1, 2
    • Systemic reviews and meta-analyses have suggested the potential role of ginger supplementation to prevent acute nausea and vomiting from chemotherapy and during pregnancy 3, 4

    Artichoke Extract 4:1 500mg

    • In a large open study of 500 patients with upper GI symptoms, supplementation with at least 320mg of artichoke leaf extract resulted in a 40% reduction in the global dyspepsia score and improved health related quality of life 5
    • In a placebo controlled, double-blind, randomized controlled trial of 247 patients with functional dyspepsia, artichoke leaf extract was significantly better than placebo in alleviating symptoms and improving disease-specific quality of life 6
    • When used together, ginger and artichoke supplementation have a synergistic effect and provide a marked advantage over placebo with regards to alleviating nausea, epigastric fullness, epigastric pain, and bloating compared to placebo in a double blind, randomized, placebo-controlled trial 7

    Oregano Leaf Extract 300mg

    • Oregano oils are well known to contain anti-bacterial activity 8, 9, and this can guard against diseases like small intestinal bacterial overgrowth (SIBO), which can cause bloating and diarrhea. Patients on GLP-1 agonists may be more prone to SIBO as these drugs cause a general slowing of the digestive tract (dysmotility)
    • A 2014 study of 104 patients with SIBO (diagnosed via lactulose breath test) showed that herbal therapy containing oregano oil is at least as effective as Rifaximin for resolution of SIBO. 46% of patients treated with herbal medication experienced symptom improvement compared with only 34% treated with the antibiotic rifaximin. Furthermore, 57% of patients offered herbal therapy after not responding to Rifaximin were actually treated successfully with herbal therapy confirmed by a subsequent negative lactulose breath test 10
    • Carvacrol rich preparations may exert more of an antibacterial effect and are rich in anti-oxidants. They are particularly effective against food-borne pathogens such as E coli, Salmonella and Bacillus cereus 11, 12

    Peppermint Leaf Powder 50mg

    • Several studies have shown that peppermint oil can help treat IBS symptoms such as diarrhea, bloating, abdominal discomfort, and constipation 13-15
    • A double blind, placebo controlled trial of 74 patients with diarrhea predominant IBS (IBS-D) found that those receiving peppermint oil had significantly lower pain scores while taking the herb compared to placebo at 6 weeks of therapy 13
    • A smaller randomized, crossover study of 10 healthy volunteers suggests that peppermint oil may enhance gastric emptying and thus mitigate some of the side effects of GLP-1 treatment 16
    • A randomized, cross-over study of 120 patients with functional dyspepsia found that patients assigned to a herbal preparation with peppermint leaf extract had a significantly reduced gastrointestinal symptom score (GIS) at 4 weeks and 8 weeks compared to placebo 17

    DigeZyme 50mg

    • DigeZyme is a unique blend of digestive enzymes that aid the digestion and absorption of nutrients. It is derived from non-animal sources such as bacteria and fungi.
    • In a randomized, double-blind, placebo controlled study of 40 patients with functional dyspepsia, patients taking DigeZyme had significantly increased quality of life scores as measured by the Short-Form Leeds Dyspepsia Questionnaire (SF-LDQ), Nepean Dyspepsia Index-Short Form (NDI-SF), Visual Analog Scale (VAS), Clinical Global Impression Severity Rating Scale (CGI-S), and Glasgow Dyspepsia Severity Score (GDSS) compared with placebo (P value ranging from .0401 to .0033) 18

    Papain (papaya extract) 45mg

    • Papaya enzymes such as papain can help break down dietary proteins in the stomach leading to an improvement in indigestion, bloating and gas
    • A randomized, double-blind placebo controlled trial of 40 patients with gastrointestinal upset found that patients taking a papaya preparation had significant improvements in bloating and constipation compared with placebo 19

    Lactobaccilus Gasseri 1B CFU

    • Administration of daily Lactobacillus gasseri for 4 weeks has been shown to improve quality of life and clinical symptoms in patients with irritable bowel syndrome 20
    • Lactobacillus gasseri may have an independent effect on weight loss in addition to GLP-1 treatment
    • One randomized control trial of 87 adults with obesity found that milk enriched with lactobacillus gasseri led to a significant reduction in abdominal adiposity and body weight 21, 22
    • A second randomized, controlled trial of 90 volunteers with BMI 25 to 35 kg/m2 found that visceral adipose tissue was significantly reduced among patients taking lactobacillus gasseri daily for 12 weeks compared to placebo (p=0.038) 23

References

  1. Giacosa A, Morazzoni P, Bombardelli E, et al. Can nausea and vomiting be treated with ginger extract? Eur Rev Med Pharmacol Sci 2015;19:1291-6.
  2. Marx W, Kiss N, Isenring L. Is ginger beneficial for nausea and vomiting? An update of the literature. Curr Opin Support Palliat Care 2015;9:189-95.
  3. ​Choi J, Lee J, Kim K, et al. Effects of Ginger Intake on Chemotherapy-Induced Nausea and Vomiting: A Systematic Review of Randomized Clinical Trials. Nutrients 2022;14.
  4. ​Viljoen E, Visser J, Koen N, et al. A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting. Nutr J 2014;13:20.
  5. ​Marakis G, Walker AF, Middleton RW, et al. Artichoke leaf extract reduces mild dyspepsia in an open study. Phytomedicine 2002;9:694-9.
  6. ​Holtmann G, Adam B, Haag S, et al. Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia: a six-week placebo-controlled, double-blind, multicentre trial. Aliment Pharmacol Ther 2003;18:1099-105.
  7. ​Giacosa A, Guido D, Grassi M, et al. The Effect of Ginger (Zingiber officinalis) and Artichoke (Cynara cardunculus) Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial. Evid Based Complement Alternat Med 2015;2015:915087.
  8. ​Saeed S, Tariq P. Antibacterial activity of oregano (Origanum vulgare Linn.) against gram positive bacteria. Pak J Pharm Sci 2009;22:421-4.
  9. Sienkiewicz M, Wasiela M, Głowacka A. [The antibacterial activity of oregano essential oil (Origanum heracleoticum L.) against clinical strains of Escherichia coli and Pseudomonas aeruginosa]. Med Dosw Mikrobiol 2012;64:297-307.
  10. ​Chedid V, Dhalla S, Clarke JO, et al. Herbal therapy is equivalent to rifaximin for the treatment of small intestinal bacterial overgrowth. Glob Adv Health Med 2014;3:16-24.
  11. ​Hao Y, Li J, Shi L. A Carvacrol-Rich Essential Oil Extracted From Oregano (Origanum vulgare "Hot & Spicy") Exerts Potent Antibacterial Effects Against Staphylococcus aureus. Front Microbiol 2021;12:741861.
  12. ​Sharifi-Rad M, Varoni EM, Iriti M, et al. Carvacrol and human health: A comprehensive review. Phytother Res 2018;32:1675-1687.
  13. ​Alam MS, Roy PK, Miah AR, et al. Efficacy of Peppermint oil in diarrhea predominant IBS - a double blind randomized placebo - controlled study. Mymensingh Med J 2013;22:27-30.
  14. ​Cappello G, Spezzaferro M, Grossi L, et al. Peppermint oil (Mintoil) in the treatment of irritable bowel syndrome: a prospective double blind placebo-controlled randomized trial. Dig Liver Dis 2007;39:530-6.
  15. ​Ford AC, Talley NJ, Spiegel BM, et al. Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis. Bmj 2008;337:a2313.
  16. ​Inamori M, Akiyama T, Akimoto K, et al. Early effects of peppermint oil on gastric emptying: a crossover study using a continuous real-time 13C breath test (BreathID system). J Gastroenterol 2007;42:539-42.
  17. ​Madisch A, Holtmann G, Mayr G, et al. Treatment of functional dyspepsia with a herbal preparation. A double-blind, randomized, placebo-controlled, multicenter trial. Digestion 2004;69:45-52.
  18. ​Majeed M, Majeed S, Nagabhushanam K, et al. Evaluation of the Safety and Efficacy of a Multienzyme Complex in Patients with Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study. J Med Food 2018;21:1120-1128.
  19. ​Muss C, Mosgoeller W, Endler T. Papaya preparation (Caricol®) in digestive disorders. Neuro Endocrinol Lett 2013;34:38-46.
  20. ​Nobutani K, Sawada D, Fujiwara S, et al. The effects of administration of the Lactobacillus gasseri strain CP2305 on quality of life, clinical symptoms and changes in gene expression in patients with irritable bowel syndrome. J Appl Microbiol 2017;122:212-224.
  21. ​Kadooka Y, Sato M, Imaizumi K, et al. Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial. Eur J Clin Nutr 2010;64:636-43.
  22. ​Kadooka Y, Sato M, Ogawa A, et al. Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults in a randomised controlled trial. Br J Nutr 2013;110:1696-703.
  23. ​Kim J, Yun JM, Kim MK, et al. Lactobacillus gasseri BNR17 Supplementation Reduces the Visceral Fat Accumulation and Waist Circumference in Obese Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. J Med Food 2018;21:454-461.

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